Does Administration of Vitamin C Improves Osteoporosis in Post-Menopausal Women- A Single Center Randomized Case Control Study

Osteoporosis in elderly is a worldwide problem with high cost on health care systems Prevention of osteoporosis and its associated fractures, improves quality of life, and reduces the financial burden of treatment costs. Standard treatment regimen includes bisphosphonate, calcium, and Vitamin D3. In this paper we have studied the eect of daily administration Vitamin C on osteoporosis improvement.

In this study we have shown that Vitamin C, an aordable drug, in combination with standard therapy of osteoporosis; calcium carbonate tablets (500 mg) 3 times daily, alendronate tablet (70 mg) weekly, and Vitamin D3 injection(600 000IU )monthly, has positive eect on increase of BMD in osteoporosis

Vitamin B12 deficiency may be an important modifiable risk factor for osteoporosis.


Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies

We aimed to systematically review available data on the association between vitamin C intake and bone mineral density (BMD), as well as risk of fractures and osteoporosis, and to summarise this information through a meta-analysis. Previous studies on vitamin C intake in relation to BMD and risk of fracture and osteoporosis were selected through searching PubMed, Scopus, ISI Web of Science and Google Scholar databases

In conclusion, we found that greater dietary vitamin C intake was associated with higher BMD at the femoral neck and lumbar spine. In addition, reduced risk of hip fracture and osteoporosis were associated with greater dietary vitamin C intakes.


Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects

Bone-related diseases are very common problems, especially in the elderly population. Zinc takes part in the growth and maintenance of healthy bones. This meta-analysis aims to evaluate the effects of zinc supplementation or dietary zinc intake on serum zinc levels and bone turnover markers.

In conclusion, serum zinc level and dietary zinc intake could have an essential role in preventing osteoporosis. Zinc supplementation might improve bone turnover markers for bone formation such as serum osteocalcin and serum alkaline phosphatase and also, BMD at the site of the femoral neck.


Role of nutritional zinc in the prevention of osteoporosis

Zinc is known as an essential nutritional factor in the growth of the human and animals. Bone growth retardation is a common finding in various conditions associated with dietary zinc deficiency. Bone zinc content has been shown to decrease in aging, skeletal unloading, and postmenopausal conditions, suggesting its role in bone disorder. Zinc has been demonstrated to have a stimulatory effect on osteoblastic bone formation and mineralization; the metal directly activates aminoacyl-tRNA synthetase, a rate-limiting enzyme at translational process of protein synthesis, in the cells, and it stimulates cellular protein synthesis. Zinc has been shown to stimulate gene expression of the transcription factors runt-related transcription factor 2 (Runx2) that is related to differentiation into osteoblastic cells. Moreover, zinc has been shown to inhibit osteoclastic bone resorption due to inhibiting osteoclast-like cell formation from bone marrow cells and stimulating apoptotic cell death of mature osteoclasts. Zinc has a suppressive effect on the receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced osteoclastogenesis. Zinc transporter has been shown to express in osteoblastic and osteoclastic cells. Zinc protein is involved in transcription. The intake of dietary zinc causes an increase in bone mass. β-Alanyl-L-histidinato zinc (AHZ) is a zinc compound, in which zinc is chelated to β-alanyl-L-histidine. The stimulatory effect of AHZ on bone formation is more intensive than that of zinc sulfate. Zinc acexamate has also been shown to have a potent-anabolic effect on bone. The oral administration of AHZ or zinc acexamate has the restorative effect on bone loss under various pathophysiologic conditions including aging, skeletal unloading, aluminum bone toxicity, calcium- and vitamin D-deficiency, adjuvant arthritis, estrogen deficiency, diabetes, and fracture healing. Zinc compounds may be designed as new supplementation factor in the prevention and therapy of osteoporosis.


The Potential of Probiotics as a Therapy for Osteoporosis

Osteoporosis, characterized by low bone mass and micro-architectural deterioration of bone tissue with increased risk of fracture, can be categorized into two forms: primary or secondary, depending on whether it occurs as part of the natural aging process (estrogen-deficiency) or as part of disease pathology. In both forms bone loss is due to an imbalance in the bone remodeling process with resorption/formation skewed more toward bone loss. Recent studies and emerging evidence consistently demonstrate the potential of the intestinal microbiota to modulate bone health. The current chapter discusses the process of bone remodeling and the pathology of osteoporosis and introduces the intestinal microbiota and its potential to influence bone health. In particular, we highlight recent murine studies that examine how probiotic supplementation can both increase bone density in healthy individuals as well as protect against primary (estrogen-deficiency) as well as secondary osteoporosis. Potential mechanisms are described to account for how probiotic treatments could be exerting their beneficial effect on bone health.

Osteoporosis is a devastating complication of the skeleton that has profound influence on the quality of life. It is critical that we continue to develop new, safe and effective strategies to prevent or treat osteoporosis associated with different conditions and variables (age, biological sex, disease, genetic background). Effect of probiotics in animal models suggests that oral probiotic supplementation could be a safe and effective alternative for preventing bone loss in various conditions in humans including menopause and T1D as well as enhance bone density under healthy or modestly inflamed conditions.


Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial

Results of this pilot study suggest that adjunctive treatment with Bacillus coagulans GBI-30, 6086 LAB probiotic appeared to be a safe and effective for patients suffering from rheumatoid arthritis.