FORTIUS MAG+ Resveratrol

Food supplement

200mg organic Magnesium *
(100mg Magnesium bisglycinate + 100mg Magnesium citrate SR )

25mg ( trans-Resveratrol (as Veri-Sperse®) *

15mg Vitamin B6 (as Pyridoxine hydrochloride)*

* per daily dose (2 tablets)

60 dispersible tablets

Introduction

Innovative formulation contains two types of magnesium, in a total amount of 200 mg, 25 mg of Veri-Sperse trans Resveratrol and 15 mg of Vitamin B6, per daily dose.

• In the form of dispersible tablets for maximum absorption.

Forms per element

Magnesium

Two types of magnesium are used in FORTIUS MAG + Resveratrol for maximum bioavailability and absorption:

– Magnesium bisglycinate: Chelated form of magnesium that provides the highest levels of absorption and bioavailability and does not cause gastrointestinal side effects e.g. diarrhea, like other forms of magnesium.
In addition, its absorption is not disturbed by other nutrients.[3]

– Magnesium citrate SR: Organic magnesium salt of sustained release, which achieves greater absorption than inorganic.[4]

Resveratrol

In FORTIUS MAG + Resveratrol, Veri-SperseTM trans resveratrol has been used, a form of resveratrol that offers maximum absorption and bioavailability.

The bioavailability of Veri-SperseTM resveratrol is almost twice than that of standard resveratrol at an equal dose, and the maximum concentration (Cmax) is three times higher.[7]

Bidirectional synergistic action of Magnesium and Resveratrol

Composition

Dosage
2 dispersible tablets daily (morning – evening) or as directed by a healthcare professional.

Magnesium

► Magnesium is a vital mineral for the proper functioning of the body which is involved in more than 600 enzyme reactions.

► It is essential for the health of the heart and blood vessels, brain, bones, muscles and lungs.

► It has a regulatory role in energy metabolism, protein synthesis, muscle and nerve function, blood glucose and blood pressure control.

According to international bibliography:

Contributes to:

• reduction of tiredness and fatigue
• electrolyte balance
• normal energy-yielding metabolism
• normal functioning of the nervous system
• normal muscle function
• normal protein synthesis
• normal psychological function
• maintenance of normal bones
• maintenance of normal teeth
• has a role in the process of cell division

Resveratrol

Resveratrol belongs to polyphenols and is a powerful antioxidant found mainly in grapes and berries (blueberries, cranberries).

• It plays a beneficial role in the prevention and progression of chronic diseases related to inflammation such as diabetes, obesity, cardiovascular diseases.
• Through its multiple biological activities it exhibits anti-aging and anti-inflammatory properties and protective effects on the brain, heart and circulatory system.
• Can reduce levels of muscle damage, inflammation and pain.
• Associated with beneficial effects on bone mineral density in Type 2 diabetes mellitus patients.
• Taking resveratrol during pregnancy and lactation has been associated with a reduced risk of maternal obesity, gestational diabetes and preeclampsia.
• It is widely recognized to have protective effects against obesity and related metabolic disorders.

References

1. Fiorentini D et al, Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency. Nutrients. 2021 Apr; 13(4): 1136.

2,Rathbone M J et al, The oral cavity as a site for systemic drug delivery. Advanced Drug Delivery Reviews, 13 (1994) 1-22.

3.Vynckier A K et al, Type of Magnesium Salt and Formulation Solubility Determines Bioavailability of Magnesium Food Supplements. J Nutr Food Sci, 2020 Oct; 10 (5): 781.

4.Lindberg J S et al, Magnesium bioavailability from magnesium citrate and magnesium oxide. J Am Coll Nutr. 1990 Feb;9(1):48-55.

5.Commission regulation (EU) No 432/2012 of 16 May 2012, Official Journal of the European Union.

6.Pannu N et al, Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases. Biomed Pharmacother. 2019 Jan;109:2237-2251.

7.Iannitti R G et al, Resveratrol Supported on Magnesium DiHydroxide (Resv@MDH) Represents an Oral Formulation of Resveratrol With Better Gastric Absorption and Bioavailability Respect to Pure Resveratrol. Front Nutr. 2020; 7: 570047.

8. Briskey D. L et al, Trans-Resveratrol Oral Bioavailability in Humans. Using LipiSperseTM Dispersion Technology. Pharmaceutics 2020, 12, 1190. 9. Parra M et al, Vitamin B6 and Its Role in Cell Metabolism and Physiology. Cells 2018 Jul; 7(7): 84.

9. Parra M et al, Vitamin B6 and Its Role in Cell Metabolism and Physiology. Cells 2018 Jul; 7(7): 84.